2-Chloro-5-nitronicotinic acid

CAS: 151322-83-7

Ref. 3D-FC51033

Produktinformation

• Name: 2-Chloro-5-nitronicotinic acid
• Synonyme: 2-Chloro-5-nitro-3-pyridinecarboxylic acid, Ethyl 2-chloro-5-nitronicotinate, Ethyl 2-Chloro-5-Nitropyridine-3-Carboxylate

Beschreibung

2-Chloro-5-nitronicotinic acid is a potent inhibitor of HIV-1 reverse transcriptase. It has been shown to inhibit the transcription of HIV-1 with an IC50 value of 0.3 μM, as well as other retroviruses in vitro. 2-Chloro-5-nitronicotinic acid binds reversibly to the active site of the enzyme and inhibits its activity. The binding site for this drug is located at the Y181C position, which is a mutation that renders the enzyme more sensitive to inhibition by 2-chloro-5 nitronicotinic acid than wild type HIV enzymes.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 230.6 g/mol
• Formel: C₈H₇ClN₂O₄
• Reinheit: Min. 95%