DIC

CAS: 693-13-0

Ref. 3D-FD02073

Produktinformation

• Name: DIC
• Synonyme: 1,3-Diisopropylcarbodiimide N,N'-Diisopropylcarbodiimide
• Marke: Biosynth
• Beschreibung: DIC is a carbodiimide used as a coupling reagent for amide and ester formation, widely employed in peptide synthesis in presence of additives such as HOBt or HOAt to supress racemisation. Being a liquid, DIC is easier to handle than the solid DCC and forms a DCM-soluble urea by-product, while DCC generates a urea by-product insoluble in most organic solvents. Since the presence of insoluble urea is reportedly problematic in solid-phase peptide synthesis, for this application DIC is more suitable than DCC. A possible side-reaction with DIC and carbodiimides in general is the formation of an N-acylurea, which can be limited by conducting the reaction in DCM or chloroform at low temperatures, and by adding the amine at last.

Chemische Eigenschaften

• Molekulargewicht: 126.2 g/mol
• Formel: C₇H₁₄N₂
• Reinheit: Min. 99.0%
• Farbe/Form: Colorless Clear Liquid
• InChl: InChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
• InChI Key: InChIKey=BDNKZNFMNDZQMI-UHFFFAOYSA-N
• SMILES: CC(C)N=C=NC(C)C