DCC

CAS: 538-75-0

Ref. 3D-FD05508

Produktinformation

• Name: DCC
• Synonyme: 1,3-Dicyclohexyl carbodiimideN,N'-Dicyclohexylcarbodiimide
• Marke: Biosynth
• Beschreibung: DCC is a carbodiimide coupling reagent for amide and ester formation, used in peptide synthesis in presence of benzotriazole-based additives such as HOBt or HOAt to limit epimerisation. The urea by-product is highly insoluble in water and most organic solvents; therefore it can be easily removed by filtration. The insolubility of the urea makes the use of DCC unsuitable for solid-phase peptide synthesis unlike DIC, and only suitable for solution-phase couplings. Carbodiimide reagents including DCC tend to generate an N-acylurea by-product, whose formation can be controlled by forming the activated ester first and adding the amine afterwards, together with low reaction temperatures and the choice of DCM or chloroform as solvent.

Chemische Eigenschaften

• Molekulargewicht: 206.33 g/mol
• Formel: C₁₃H₂₂N₂
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder
• InChl: InChI=1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2
• InChI Key: InChIKey=QOSSAOTZNIDXMA-UHFFFAOYSA-N
• SMILES: C(=NC1CCCCC1)=NC1CCCCC1