4,6-Dichloronicotinaldehyde

CAS: 1060811-62-2

Ref. 3D-FD143587

Produktinformation

• Name: 4,6-Dichloronicotinaldehyde
• Synonyme: 4,6-dichloro-3-Pyridinecarboxaldehyde, 4,6-Dichloropyridine-3-carboxaldehyde

Beschreibung

4,6-Dichloronicotinaldehyde is a potent inhibitor of the enzyme kinase Plk1. It inhibits the activity of this enzyme by binding to the ATP-binding site, thereby blocking ATP hydrolysis and inhibiting cell division. The IC50 for 4,6-dichloronicotinaldehyde is in the nanomolar range. This compound has been shown to inhibit cells with a specific phenotype, such as human mammary epithelial cells (HMEC), while not affecting other cell types such as HeLa cells. 4,6-Dichloronicotinaldehyde has also been shown to be effective against low nanomolar concentrations of Plk1 in vitro and in vivo.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 176 g/mol
• Formel: C₆H₃Cl₂NO
• Reinheit: Min. 95%
• Farbe/Form: Solid
• InChl: InChI=1S/C6H3Cl2NO/c7-5-1-6(8)9-2-4(5)3-10/h1-3H
• InChI Key: InChIKey=AKYJFAHYRMPRDS-UHFFFAOYSA-N
• SMILES: O=Cc1cnc(Cl)cc1Cl