4'-Demethyl homoharringtonine

CAS: 98599-84-9

Ref. 3D-FD21000

Produktinformation

• Name: 4'-Demethyl homoharringtonine
• Synonyme: 5'-Des-O-methylhomoharringtonine

Beschreibung

Homoharringtonine is a natural drug that has been used for the treatment of cancer and other diseases. It is an antitumor agent that inhibits cell growth by affecting DNA synthesis, RNA synthesis, protein synthesis, and the activity of enzymes. Homoharringtonine also has antineoplastic effects and can be used to treat leukemia. Homoharringtonine binds to DNA in a ring-opening reaction with yields of up to 20%. This compound can be synthesized from phenylalanine and substituted with a trisubstituted benzene ring. It also catalyzes the conversion of an enamine into an iminium ion, which reacts with a second molecule of enamine to form a keto-enamine.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 531.59 g/mol
• Formel: C₂₈H₃₇NO₉
• Reinheit: Min. 95%
• InChl: InChI=1S/C28H37NO9/c1-26(2,33)7-4-9-28(34,15-22(30)31)25(32)38-24-21(35-3)14-27-8-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,33-34H,4-11,15-16H2,1-3H3,(H,30,31)/t23-,24-,27+,28-/m1/s1
• InChI Key: InChIKey=LRNKGNYRSLLFRU-KSZYUSJVSA-N
• SMILES: COC1=C[C@]23CCCN2CCc2cc4c(cc2[C@@H]3[C@@H]1OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)O)OCO4