1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one

CAS: 2898-08-0

Ref. 3D-FD29780

Produktinformation

• Name: 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one
• Synonyme: 1,2-Dihydro-5-phenyl-3H-1,4-benzodiazepin-2-one, 1,3-Dihydro-5-Phenyl-1,4-Benzodiazepin-2-One, 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-phenyl-, 5-Phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one, 5-Phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one, 5-Phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one, 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one, Dechlorodemethyldiazepam, Desmethyldechlorodiazepam, NSC 656624, Ro 05-2921, Ro 5-2921

Beschreibung

Clozapine N-oxide is a metabolite of clozapine. It has been found in the plasma of patients treated with clozapine and in urine samples from schizophrenic patients. The formation of clozapine N-oxide is due to the oxidative deamination of clozapine by plasma proteins such as cytochrome P450, which are present at high levels in the liver and other organs. Clozapine N-oxide is a fluorescent substance that can be detected spectrometrically. Clozapine N-oxide can be synthesized by reacting 1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-one with sodium carbonate or sodium hydroxide in an organic solvent. This compound can then be conjugated with glucuronic acid or sulfate, or undergo modifications such as oxidation to form clozapine OXN.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 236.27 g/mol
• Formel: C₁₅H₁₂N₂O
• Reinheit: Min. 95%