2,6-Dichloro-4-iodopyrimidine

CAS: 98027-84-0

Ref. 3D-FD32638

Produktinformation

• Name: 2,6-Dichloro-4-iodopyrimidine
• Synonyme: Pyridine, 2,6-dichloro-4-iodo-

Beschreibung

2,6-Dichloro-4-iodopyrimidine is a small molecule with potent anticancer activity. It is one of two compounds that were identified as potential treatments for ceralasertib-resistant pancreatic cancer cells. 2,6-Dichloro-4-iodopyrimidine inhibits the kinase activity of the protein Csk in an ATP competitive manner. This inhibitor has been synthesized by a stepwise process involving nucleophilic substitution and coupling reactions to form 2,6-dichloropyrimidine from 2,4,5-trichloropyrimidine and iodide ion. The product was then reacted with dichloromethyl chloroformate to yield 2,6-dichloro-4-iodopyrimidine following a nucleophilic substitution reaction. Other analogs have been prepared in order to alter the potency or selectivity of this compound for other targets such as tyrosine kinases and protein

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 273.89 g/mol
• Formel: C₅H₂Cl₂IN
• Reinheit: Min. 95%