5,7-Dibromo-2-methyl-8-quinolinol

CAS: 15599-52-7

Ref. 3D-FD34448

Produktinformation

• Name: 5,7-Dibromo-2-methyl-8-quinolinol
• Synonyme: 2-Methyl-5,7-dibromo-8-hydroxyquinoline, 5,7-Dibromo-2-Methylquinolin-8-Ol, 5,7-Dibromo-2-methyl-8-hydroxyquinoline, 5,7-Dibromo-8-hydroxy-2-methylquinoline, 5,7-Dibromo-8-hydroxyquinaldine, 8-Quinolinol, 5,7-dibromo-2-methyl-, Broquinaldol, NSC 85838

Beschreibung

5,7-Dibromo-2-methyl-8-quinolinol (DBMQ) is a quinoline derivative that has been shown to have anticancer activity. It inhibits tumor cell growth and induces apoptosis by disrupting the mitochondrial membrane potential (Δψ) and mitochondrial functions. DBMQ also has high cytotoxicity, which makes it a promising candidate for diagnostic and therapeutic applications. The compound binds to aluminium ions with a coordination geometry similar to that of phosphate groups, thereby inhibiting the ATP synthase in the mitochondria. This inhibition leads to decreased production of ATP, causing cells to enter apoptosis. DBMQ has been shown to be effective in treating cancer cells that are resistant to common chemotherapeutic drugs such as cisplatin and doxorubicin.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 316.98 g/mol
• Formel: C₁₀H₇Br₂NO
• Reinheit: Min. 95%
• InChl: InChI=1S/C10H7Br2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3
• InChI Key: InChIKey=BNACJQWJZKPAPV-UHFFFAOYSA-N
• SMILES: Cc1ccc2c(Br)cc(Br)c(O)c2n1