3,5-Difluorobenzyl bromide

CAS: 141776-91-2

Ref. 3D-FD49123

Produktinformation

• Name: 3,5-Difluorobenzyl bromide
• Synonyme: α-Bromo-3,5-difluorotoluene, 1-(Brommethyl)-3,5-difluorbenzol, 1-(Bromomethyl)-3,5-difluorobenzene, 141776-91-2, Benzene, 1-(bromomethyl)-3,5-difluoro-, Fr Cf E1E, 2,4,4,5,7,7,8,10,10,11,13,13,14,14,15,15,15-Heptadecafluoro-2,5,8,11-Tetrakis(Trifluoromethyl)-3,6,9,12-Tetraoxapentadecan-1-Ol, 5-Fluoro-2-formylbenzeneboronic acid, 5-Fluoro-2-formylphenylboronic acid

Beschreibung

3,5-Difluorobenzyl bromide (3,5-DFB) is a molecule that is used to inhibit the activity of protein kinases. It binds to the ATP binding site of these enzymes and prevents ATP from binding. This leads to a reduced ability of the protein kinase to phosphorylate other proteins. 3,5-Difluorobenzyl bromide has been shown to inhibit influenza virus replication in vitro and in vivo. X-ray crystal structures have shown that 3,5-DFB binds to an active site on the viral RNA polymerase complex, where it interacts with viral nucleotides and blocks their incorporation into viral RNA chains. 3,5-DFB also inhibits virus strain A/WSN/33 (H1N1) in cell culture at concentrations of 5 μM or less.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 207.02 g/mol
• Formel: C₇H₅BrF₂
• Reinheit: Min. 95%
• Farbe/Form: Clear Liquid
• InChl: InChI=1S/C7H5BrF2/c8-4-5-1-6(9)3-7(10)2-5/h1-3H,4H2
• InChI Key: InChIKey=KVSVNRFSKRFPIL-UHFFFAOYSA-N
• SMILES: Fc1cc(F)cc(CBr)c1