R-(+)-Etomoxir

CAS: 124083-20-1

Ref. 3D-FE23200

Produktinformation

• Name: R-(+)-Etomoxir
• Synonyme: (R)-2-[6-(4-Chlorophenoxy)hexyl]oxiranecarboxylic acid, ethyl ester, (R)-(+)-Etomoxir, (R)-Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate, 2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-, Ethyl (+)-(R)-2-(6-(p-chlorophenoxy)hexyl)glycidate, Etomoxir [INN], Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-, Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (R)-, Unii-Msb3Dd2Xp6, ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, ethyl (2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate

Beschreibung

Etomoxir is a potent inhibitor of the mitochondrial enzyme, fatty acid: 2-enoyl-CoA reductase. This enzyme catalyzes the conversion of long-chain acyl-CoA to acetyl-CoA, which is required for the synthesis of mitochondrial membrane phospholipids and cardiolipin. Etomoxir inhibits this activity and consequently prevents the production of ATP. It also inhibits oxidative phosphorylation in isolated mitochondria and reduces locomotor activity in rats. Etomoxir has been shown to have inhibitory properties on human malignant brain cells as well as breast cancer cells (MDA-MB-231).

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 326.81 g/mol
• Formel: C₁₇H₂₃ClO₄
• Reinheit: Min. 95%
• InChl: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
• InChI Key: InChIKey=DZLOHEOHWICNIL-QGZVFWFLSA-N
• SMILES: CCOC(=O)[C@@]1(CCCCCCOc2ccc(Cl)cc2)CO1