2-Fluoroadenine

CAS: 700-49-2

Ref. 3D-FF05946

Produktinformation

• Name: 2-Fluoroadenine
• Synonyme: 2-Fluoro-6-aminopurine6-Amino-2-fluoropurine, 1H-Purin-6-amine, 2-fluoro-, 2-Fluoro-1H-purin-6-amine, 2-Fluoro-6-aminopurine, 2-Fluoro-7(9)H-purin-6-ylamine, 2-Fluoro-7H-purin-6-amine, 2-Fluoro-9H-purin-6-amine, 9H-Purin-6-amine, 2-fluoro-, Adenine, 2-fluoro-, NSC 27364

Beschreibung

2-Fluoroadenine is an inhibitor of DNA synthesis, which is used to study the effect of carcinogens on the cell cycle. It is a potent inducer of G2/M arrest in HL-60 cells, and has been shown to be cytotoxic to a number of different carcinoma cell lines. 2-Fluoroadenine disrupts collagen gel networks by binding to nitrogens in the protein matrix. This inhibits the glycosylation process that stabilizes collagen networks. The use of 2-fluoroadenine as a chemotherapeutic agent has been studied in animal models and clinical trials. 2-Fluoroadenine has been shown to inhibit mitochondrial membrane potential, leading to apoptosis caused by oxidative stress.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 153.12 g/mol
• Formel: C₅H₄FN₅
• Reinheit: Min. 98 Area-%
• Farbe/Form: Off-White Powder
• InChl: InChI=1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
• InChI Key: InChIKey=WKMPTBDYDNUJLF-UHFFFAOYSA-N
• SMILES: Nc1nc(F)nc2nc[nH]c12