4-Fluorophenyl isocyanate

CAS: 1195-45-5

Ref. 3D-FF07776

Produktinformation

• Name: 4-Fluorophenyl isocyanate
• Synonyme: 1-Fluoro-4-Isocyanatobenzene, 4-Fluoro-1-isocyanatobenzene, 4-Fluoroisocyanatobenzene, 4-Flurophenyl isocyanate, Benzene, 1-fluoro-4-isocyanato-, Isocyanic acid, p-fluorophenyl ester, NSC 82348, p-Fluorobenzene isocyanate, p-Fluorophenyl isocyanate
• CAS: 1195-45-5

Beschreibung

4-Fluorophenyl isocyanate is a hydroxylated derivative of phenyl isocyanate. It has been shown to have anticancer activity, with an IC50 value of about 50 μM. 4-Fluorophenyl isocyanate can be synthesized by reacting 3-bromopropylamine hydrobromide with hydrogen fluoride in the presence of a carbodiimide. The reaction can be optimized by adding epoxides or carbodiimides, and the best conditions are found to be at pH 10 and room temperature. 4-Fluorophenyl isocyanate binds to the MT2 receptor which leads to activation of G proteins, resulting in increased intracellular cAMP levels.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 137.11 g/mol
• Formel: C₇H₄FNO
• Reinheit: Min. 95%
• InChl: InChI=1S/C7H4FNO/c8-6-1-3-7(4-2-6)9-5-10/h1-4H
• InChI Key: InChIKey=DSVGFKBFFICWLZ-UHFFFAOYSA-N
• SMILES: O=C=Nc1ccc(F)cc1