[(1R,2S,3S,4S,5R,6S)-5-Fluoro-2,4-Dihydroxy-3,6-Diphosphonooxycyclohexyl] Dihydrogen Phosphate

CAS: 144371-38-0

Ref. 3D-FF102035

Produktinformation

• Name: [(1R,2S,3S,4S,5R,6S)-5-Fluoro-2,4-Dihydroxy-3,6-Diphosphonooxycyclohexyl] Dihydrogen Phosphate
• Synonyme: (1S,2R,3S,4S,5S,6R)-6-fluoro-3,5-dihydroxycyclohexane-1,2,4-triyl tris[dihydrogen (phosphate)], 3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate, 3-Deoxy-3-fluoro-ins(1,4,5)P3, 3-F-Insp3, <span class="text-smallcaps">D</span>-myo-Inositol, 3-deoxy-3-fluoro-, 1,4,5-tris(dihydrogen phosphate), D-myo-Inositol, 3-deoxy-3-fluoro-1,4,5-tris(dihydrogen phosphate), Ins(1,4,5)P(3)F

Beschreibung

[(1R,2S,3S,4S,5R,6S)-5-Fluoro-2,4-Dihydroxy-3,6-Diphosphonooxycyclohexyl] Dihydrogen Phosphate (FPP) is a membrane hyperpolarizing agent that has been shown to activate mouse hippocampal neurons. FPP selectively blocks the calcium permeability of non-selective cation channels and enhances cytosolic calcium concentration by blocking the endoplasmic reticulum release of Ca2+. The main pharmacological action of FPP is on voltage-gated calcium channels. FPP also blocks L-, N-, P/Q-, and R-type voltage gated calcium channels. When applied at micron concentrations in cultured cells, FPP inhibits the activity of phospholipase C (PLC), which causes an increase in cytosolic free Ca2+ concentration. This leads to a range of

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 422.09 g/mol
• Formel: C₆H₁₄FO₁₄P₃
• Reinheit: Min. 95%