Produktinformation
Name:
5-Formylimidazole-4-carboxylic acid methylester
Synonyme:
- 1H-imidazole-4-carboxylic acid, 5-formyl-, methyl ester
- Methyl 5-formyl-1H-imidazole-4-carboxylate
Beschreibung:
5-Formylimidazole-4-carboxylic acid methylester (5FICM) is a small molecule that has been shown to inhibit the growth of cells by blocking the TNF-α receptor. The molecular modeling data and crystallographic data indicate that 5FICM can bind to the kinase domain of TNF-α receptors, preventing activation of downstream signaling pathways. In knockout mice, 5FICM was found to reduce skin inflammation caused by LPS. It also inhibited tumor necrosis factor (TNF)-α production in epidermal growth factor (EGF)-treated human keratinocytes and inhibited EGF-induced epidermal growth. These data suggest that 5FICM may be a potential therapeutic agent for inflammatory skin diseases, such as psoriasis and atopic dermatitis.
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Marke:
Biosynth
Langzeitlagerung:
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Chemische Eigenschaften
Molekulargewicht:
154.12 g/mol
Formel:
C6H6N2O3
Reinheit:
Min. 95%
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