Fmoc-D-isoleucine

CAS: 143688-83-9

Ref. 3D-FF31391

Produktinformation

• Name: Fmoc-D-isoleucine
• Synonyme: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-isoleucine, (2S,3S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoate

Beschreibung

Fmoc-D-isoleucine is a cyclic peptide that inhibits the enzyme dipeptidyl peptidase IV (DPP-IV). It has been shown to have a cytotoxic effect on tumor cells. Fmoc-D-isoleucine binds to DPP-IV in a competitive manner and prevents the enzyme from breaking down the amino acid sequence of proinsulin, which is necessary for normal cell growth. The effective dose of Fmoc-D-isoleucine is between 5 and 10 micromolar, with an IC50 of approximately 4 micromolar. This peptide also binds to sodium ions and hydroxyl groups, and forms disulfide bonds with silver ions, which can be used for further structural analysis. Fmoc-D-isoleucine has been shown to inhibit neurodegeneration in animal models by binding to iron and preventing its oxidation.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 353.41 g/mol
• Formel: C₂₁H₂₃NO₄
• Reinheit: Min. 95%
• Farbe/Form: White Powder