Harringtonine

CAS: 26833-85-2

Ref. 3D-FH15975

Produktinformation

• Name: Harringtonine
• Synonyme: 3-4-Methyl-(2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioatecephalotaxine
• Marke: Biosynth
• Beschreibung: Harringtonine is a plant-derived alkaloid, which is isolated from the seeds of the Cephalotaxus species. It functions primarily by inhibiting protein synthesis within eukaryotic cells, targeting the elongation step of translation. Harringtonine binds to the ribosomal A-site cleft, halting the proper addition of amino acids to the growing polypeptide chain and thereby inducing apoptosis in rapidly dividing cells.

Chemische Eigenschaften

• Molekulargewicht: 531.59 g/mol
• Formel: C₂₈H₃₇NO₉
• Reinheit: Min. 95%
• Farbe/Form: White Off-White Powder
• InChl: InChI=1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1
• InChI Key: InChIKey=HAVJATCHLFRDHY-KSZYUSJVSA-N
• SMILES: COC(=O)C[C@](O)(CCC(C)(C)O)C(=O)O[C@@H]1C(OC)=C[C@]23CCCN2CCc2cc4c(cc2[C@H]13)OCO4