Darunavir

CAS: 206361-99-1

Ref. 3D-FH20801

Produktinformation

• Name: Darunavir
• Synonyme: [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic acid (3R,3aS,6aR)-hexahydrof uro[2,3-b]-furan-3-yl esterTMC-114UIC-94017[(3R,3aS,6aR)-2,3,3a,4,5,6a-Hexahydrofuro[5,4-b]furan-3-yl] N-[(2S,3R)-4
• Marke: Biosynth
• Beschreibung: Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.

Chemische Eigenschaften

• Molekulargewicht: 547.66 g/mol
• Formel: C₂₇H₃₇N₃O₇S
• Reinheit: Min. 95%
• Farbe/Form: White Powder