4-Hydroperoxy cyclophosphamide
CAS: 39800-16-3
Ref. 3D-FH23893
1mg | 406,00 € | ||
2mg | 542,00 € | ||
5mg | 861,00 € | ||
10mg | 1.135,00 € | ||
25mg | 2.026,00 € |
Produktinformation
- 2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxidePerfosfamide4-HC
- (2R,4R)-2-[bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-yl hydroperoxide
- 2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide
- 2H-1,3,2-Oxazaphosphorine, hydroperoxide deriv.
- 4-Hydroperoxycyclofosfamide
- 4-Hydroperoxycyclophosphamide
- Asta 6496
- Hydroperoxide, 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl, P-oxide
- hydroperoxide, 2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl
4-Hydroperoxycyclophosphamide (4-HPPC) is a cytotoxic agent with anti-cancer properties. It is a prodrug that is converted to 4-hydroxycyclophosphamide, the active form of the drug, by hydrolases in cells. The cytotoxicity of 4-HPPC has been demonstrated using a model system of human erythrocytes and HL60 cells. This drug also has an effect on tumor growth and metastasis, as well as on bowel disease. Rats treated with 4-HPPC showed decreased levels of blood glucose, increased glutathione peroxidase activity, and a decrease in the number of colonic tumors after only one dose. The low-dose group had improved mitochondrial membrane potential and an increase in cell factor receptor activity. These results indicate that 4-HPPC may be a useful anti-cancer compound for treating various types of cancer including colon cancer.
Chemische Eigenschaften
Technische Anfrage zu: 3D-FH23893 4-Hydroperoxy cyclophosphamide
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