9-Hydroxy benzopyrene

CAS: 17573-21-6

Ref. 3D-FH23914

Produktinformation

• Name: 9-Hydroxy benzopyrene
• Synonyme: Benzo[a]pyren-9-ol, Benzo(a)pyren-9-ol, Benzo(a)pyrene, 9-hydroxy-, Benzo[Pqr]Tetraphen-9-Ol, Brn 1980310, Ccris 1073
• CAS: 17573-21-6

Beschreibung

9-Hydroxybenzopyrene is a reactive, dna binding compound. It binds to nuclear DNA and alters the transcription process. 9-Hydroxypyrene has been shown to be a potent mutagen at high doses in yeast (Saccharomyces cerevisiae) and rat liver microsomes. Low bioavailability of 9-hydroxypyrene is due to its rapid metabolism by human liver enzymes, which convert it into metabolites, such as 1'-hydroxybenzopyrene and 3'-hydroxybenzopyrene. These metabolites are also found in urine samples and have been shown to bind to cellular receptors such as epidermal growth factor receptor, leading to DNA synthesis and cell proliferation. 9-Hydroxypyrene has been shown to cause tumorigenicity in primary keratinocytes, hamster v79 cells, and model systems.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 268.31 g/mol
• Formel: C₂₀H₁₂O
• Reinheit: Min. 95%
• InChl: InChI=1S/C20H12O/c21-16-8-6-14-10-15-5-4-12-2-1-3-13-7-9-17(18(14)11-16)20(15)19(12)13/h1-11,21H
• InChI Key: InChIKey=OBBBXCAFTKLFGZ-UHFFFAOYSA-N
• SMILES: Oc1ccc2cc3ccc4cccc5ccc(c2c1)c3c45