22α-Hydroxy cholesterol

CAS: 17954-98-2

Ref. 3D-FH23942

Produktinformation

• Name: 22α-Hydroxy cholesterol
• Synonyme: (3β,22R)-Cholest-5-ene-3,22-diol(20S,22R)-Cholest-5-ene-3b,22-diol(22R)-22-Hydroxycholesterol
• Marke: Biosynth
• Beschreibung: 22a-Hydroxycholesterol is a naturally occurring, oxygenated cholesterol metabolite. It binds to the transcriptional coactivator retinoid X receptor (RXR) and inhibits the activity of certain liver enzymes. 22a-Hydroxycholesterol has been shown to have toxic effects on mouse tumors and to inhibit the production of ATP in vitro. 22a-Hydoxycholesterol also inhibits the function of ATP binding cassette (ABC) transporter proteins, which are involved in cholesterol transport from cells. The long-term toxicity of 22a-hydroxycholesterol is not well understood, although it has been shown that this metabolite can induce autoimmune diseases in rats.

Chemische Eigenschaften

• Molekulargewicht: 402.65 g/mol
• Formel: C₂₇H₄₆O₂
• Reinheit: Min. 95%