rel-2-[(3R,5S)-5-Hydroxy-2,6-dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione

CAS: 203450-07-1

Ref. 3D-FH24139

Produktinformation

• Name: rel-2-[(3R,5S)-5-Hydroxy-2,6-dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione
• Synonyme: cis-5-Hydroxy-3-phthalimidoglutarimide, 1H-isoindole-1,3(2H)-dione, 2-(5-hydroxy-2,6-dioxo-3-piperidinyl)-

Beschreibung

5'-Hydroxy thalidomide is a drug used for the treatment of leprosy and cancer. It has been shown to have immunomodulatory effects in mice with an immunodeficiency. 5'-Hydroxy thalidomide is hydroxylated by cytochrome P450 in the liver to form 5-hydroxy thalidomide, which is a potent inhibitor of tumor necrosis factor-α (TNF-α) production. The effect of 5'-hydroxy thalidomide on TNF-α production may be due to its ability to inhibit proinflammatory cytokine synthesis in human liver cells and human hepatocytes in culture.
5'-Hydroxy thalidomide also inhibits the production of TNF-α by neutrophils, monocytes, and macrophages thereby reducing inflammation.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 274.23 g/mol
• Formel: C₁₃H₁₀N₂O₅
• Reinheit: Min. 95%
• Farbe/Form: Powder