6-Hydroxy warfarin

Ref. 3D-FH24166

Produktinformation

• Name: 6-Hydroxy warfarin
• Synonyme: 4,6-Dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one3-(a-Acetonylbenzyl)-4,6-dihydroxycoumarin
• Marke: Biosynth
• Beschreibung: Warfarin is a coumarin derivative that inhibits the synthesis of vitamin K-dependent clotting factors such as prothrombin, factor VII, and factor IX. Warfarin is metabolized by glucuronide conjugates to 6-hydroxy warfarin. It also inhibits the activity of cytochrome P450 enzymes, which may result in significant interactions with drugs such as antidepressants and antipsychotics. The plasma concentrations of warfarin are increased by a number of other drugs including the anticoagulant heparin and some antibiotics such as penicillin, ampicillin, erythromycin, cefamandole, and cefuroxime. The elimination half-life of warfarin is prolonged in patients with chronic renal failure due to decreased clearance of the drug.

Chemische Eigenschaften

• Molekulargewicht: 324.33 g/mol
• Formel: C₁₉H₁₆O₅
• Reinheit: Min. 95%
• Farbe/Form: White To Off-White Solid
• InChl: InChI=1S/C19H16O5/c1-11(20)9-14(12-5-3-2-4-6-12)17-18(22)15-10-13(21)7-8-16(15)24-19(17)23/h2-8,10,14,21-22H,9H2,1H3
• InChI Key: InChIKey=IQWPEJBUOJQPDE-UHFFFAOYSA-N
• SMILES: CC(=O)CC(c1ccccc1)c1c(O)c2cc(O)ccc2oc1=O