1-(2-Hydroxyphenyl)-2-nitroethene

CAS: 3156-43-2

Ref. 3D-FH65831

Produktinformation

• Name: 1-(2-Hydroxyphenyl)-2-nitroethene
• Synonyme: 2'-Hydroxy-beta-Nitrostyrene
• Marke: Biosynth
• Beschreibung: 1-(2-Hydroxyphenyl)-2-nitroethene is an organocatalytic biomolecule that has been synthesized in an asymmetric fashion. The synthesis of the molecule relies on a squaramide and the use of intramolecular hydrogen transfer reactions to create a nitro group. The molecule was used to generate antiestrogenic activity in MDA-MB-231 breast cancer cells and MCF-7 breast cancer cells by inhibiting estrogen receptor alpha (ERα) transcriptional activity. This molecule has also been shown to be bifunctional, as it inhibits both protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) signaling pathways when applied to these cell lines. X-ray crystal structures of the molecule have been obtained with orientations that exhibit different degrees of hydrophobicity, which may be due to interactions with water molecules.

Chemische Eigenschaften

• Molekulargewicht: 165.15 g/mol
• Formel: C₈H₇NO₃
• Reinheit: Min. 95%