Lapatinib ditosylate monohydrate

CAS: 388082-78-8

Ref. 3D-FL24843

Produktinformation

• Name: Lapatinib ditosylate monohydrate
• Synonyme: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine bis(4-meth ylbenzenesulfonate) ditosylateGW-572016F ditosylateTykerb ditosylate

Beschreibung

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 943.48 g/mol
• Formel: C₂₉H₂₆ClFN₄O₄S•(C₇H₈O₃S)₂•H₂O
• Reinheit: Min. 95%