Lomeguatrib

CAS: 192441-08-0

Ref. 3D-FL65065

Produktinformation

• Name: Lomeguatrib
• Synonyme: 1H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-, 2-Amino-6-(4-bromothiophen-2-ylmethoxy)-9H-purine, 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine, 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine, 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine, 9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-, PaTrin 2
• CAS: 192441-08-0

Beschreibung

Inhibitor and pseudosubstrate of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). It is used as a sensitizer for the treatment of advanced solid tumors, including prostate, colorectal and central nervous system malignancies. Lomeguatrib inhibits the repair mechanism of DNA damage induced by alkylating agents such as temozolomide, and therefore potentiates its anti-cancer effects.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 324.96329
• Formel: C₁₀H₈BrN₅OS
• Reinheit: Min. 95%
• Farbe/Form: Solid
• InChl: InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
• InChI Key: InChIKey=JUJPKFNFCWJBCX-UHFFFAOYSA-N
• SMILES: Nc1nc(OCc2cc(Br)cs2)c2[nH]cnc2n1