6-Methoxyindole-2-carboxylic acid
CAS: 16732-73-3
Ref. 3D-FM08189
2g | 136,00 € | ||
5g | 244,00 € | ||
10g | 352,00 € | ||
25g | 548,00 € | ||
50g | 820,00 € |
Produktinformation
- 1H-Indole-2-Carboxylic Acid, 6-Methoxy-
- Akos Jy2082559
- 6-Methoxyindole-2-Carboxylic Acid
- 6-Methoxindole-2-Carboxylic Acid
6-Methoxyindole-2-carboxylic acid (6MI) is a potent inhibitor of the enzyme catechol-O-methyltransferase (COMT). This inhibition prevents the conversion of catecholamines, such as dopamine and norepinephrine, to their corresponding methylated products. COMT inhibitors are used clinically to treat Parkinson's disease and other diseases that result from excessive levels of these neurotransmitters. 6MI is also an effective inhibitor of tyrosinase activity in vitro. It has been shown to inhibit the synthesis of melanin by melanocytes and inhibits the production of eumelanin, which is responsible for black or brown skin pigments. The inhibitory potency of 6MI was found to be greater than that for kojic acid, arbutin, and hydroquinone. Optimization studies showed that 6MI was most potent at a concentration of 1 mM and had an IC50 value of 0.3 mM in
Chemische Eigenschaften
Technische Anfrage zu: 3D-FM08189 6-Methoxyindole-2-carboxylic acid
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