2-Methylimidazo[1,2-a]pyridine-3-carboxylicacid

CAS: 21801-79-6

Ref. 3D-FM147594

Produktinformation

• Name: 2-Methylimidazo[1,2-a]pyridine-3-carboxylicacid
• Synonyme: 2-Methylimidazo[1,2-A]Pyridine-3-Carboxylate, Imidazo[1,2-A]Pyridine-3-Carboxylic Acid, 2-Methyl-, NSC 156822

Beschreibung

2-Methylimidazo[1,2-a]pyridine-3-carboxylicacid is an anti-tuberculous agent that belongs to the class of rifampin. It is a pyridine derivative that inhibits bacterial growth by binding to DNA-dependent RNA polymerase and prevents transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifampin also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 176.17 g/mol
• Formel: C₉H₈N₂O₂
• Reinheit: Min. 95%
• InChl: InChI=1S/C9H8N2O2/c1-6-8(9(12)13)11-5-3-2-4-7(11)10-6/h2-5H,1H3,(H,12,13)
• InChI Key: InChIKey=FBIUGCLQMKPURJ-UHFFFAOYSA-N
• SMILES: Cc1nc2ccccn2c1C(=O)O