(R)-10-Monohydroxy-10,11-dihydro carbamazepine

CAS: 104746-03-4

Ref. 3D-FM26062

Produktinformation

• Name: (R)-10-Monohydroxy-10,11-dihydro carbamazepine
• Synonyme: (10R)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide(R)-Licarbazepine, (10R)-10,11-Dihydro-10-Hydroxy Carbamazepine, R-(-)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide,R-MHD,CGP13698, (10R)-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

Beschreibung

(R)-10-Monohydroxy-10,11-dihydro carbamazepine is a drug that has been shown to be active in vitro against human liver microsomes. It is a metabolite of carbamazepine, which is used for the treatment of neurologic disorders. (R)-10-Monohydroxy-10,11-dihydro carbamazepine has pharmacokinetic properties and plasma concentration-time curves similar to those of its parent compound. It also binds to hepatic CYP2C19 and CYP3A4 enzymes with high affinity, which leads to the inhibition of their activity. The drug has been shown to have a half life of 27 hours in CD1 mice, but it is not known how long it stays in humans.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 254.28 g/mol
• Formel: C₁₅H₁₄N₂O₂
• Reinheit: Min. 95%
• Farbe/Form: White To Off-White Solid
• InChl: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m1/s1
• InChI Key: InChIKey=BMPDWHIDQYTSHX-CQSZACIVSA-N
• SMILES: NC(=O)N1c2ccccc2C[C@@H](O)c2ccccc21