Methyl 2-chloro-5-nitrobenzoate

CAS: 6307-82-0

Ref. 3D-FM37867

Produktinformation

• Name: Methyl 2-chloro-5-nitrobenzoate
• Synonyme: 2-Chloro-5-nitrobenzoic acid methyl ester, Benzoic acid, 2-chloro-5-nitro-, methyl ester, Brn 1966320, Methylester kyseliny 2-chlor-5-nitrobenzoove, Methylester kyseliny 2-chlor-5-nitrobenzoove [Czech], NSC 44287
• CAS: 6307-82-0

Beschreibung

Methyl 2-chloro-5-nitrobenzoate is a synthetic intermediate that can be used to synthesize benzimidazole derivatives. It is a deaminated compound and the yield of this reaction depends on the acidity of the reactants. In acidic conditions, methyl 2-chloro-5-nitrobenzoate yields more diazonium ions than in basic conditions. Methyl 2-chloro-5-nitrobenzoate reacts with benzyl chloride to form an iminium ion, which then reacts with potassium carbonate to produce the desired benzimidazole derivative. This reaction has been rationalized by proposing a mechanism in which the carbonyl group of methyl 2-chloro-5-nitrobenzoate is first protonated to form an enolate ion and then reacts with an electrophilic nucleophile (e.g., benzyl chloride) to produce the desired product.

• Marke: Biosynth

Chemische Eigenschaften

• Reinheit: Min. 95%