1-Methyl-1H-pyrazole-4-sulfonyl chloride
CAS: 288148-34-5
Ref. 3D-FM59463
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Produktinformation
Name:
1-Methyl-1H-pyrazole-4-sulfonyl chloride
Synonyme:
- 1-methyl-1H-pyrazole-4-sulfonyl chloride
- 1H-Pyrazole-4-Sulfonylchloride, 1-Methyl-
- 4-Chlorosulfonylpyrazole
Beschreibung:
1-Methyl-1H-pyrazole-4-sulfonyl chloride is selective for the b-Raf protein, inhibiting it by binding to its active site on the molecule. This binding prevents ATP from binding and initiates the conformational change necessary for Raf activation. 1-Methyl-1H-pyrazole-4-sulfonyl chloride has been shown to inhibit cellular proliferation in a number of tissues including lung, colon, and prostate. The mechanism of action is hypothesized to be due to inhibition of b-Raf. The selectivity of 1MPYSC has been rationalized by profiling analyses that have identified a number of mutant molecules with different binding affinities for wild type and mutant b-Raf proteins.
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Marke:
Biosynth
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Chemische Eigenschaften
Molekulargewicht:
180.61 g/mol
Formel:
C4H5ClN2O2S
Reinheit:
Min. 95%
InChl:
InChI=1S/C4H5ClN2O2S/c1-7-3-4(2-6-7)10(5,8)9/h2-3H,1H3
InChI Key:
InChIKey=RDAVKKQKMLINOH-UHFFFAOYSA-N
SMILES:
Cn1cc(S(=O)(=O)Cl)cn1
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