Oridonin

CAS: 28957-04-2

Ref. 3D-FO09522

Produktinformation

• Name: Oridonin
• Synonyme: Isodonol7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one, (1alpha,5beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one, (1alpha,5beta,6beta,7beta,9xi,10xi,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one, (1alpha,5beta,6beta,9beta,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one, (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one, (6Beta,7Beta)-1,6,7,14-Tetrahydroxy-7,20-Epoxykaur-16-En-15-One, 6,11b-(Epoxymethano)-6a,9-methano-1H-cyclohepta[a]naphthalene, kaur-16-en-15-one deriv., Isodonal, Isodonol, Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1α,6β,7α,14R)-, Kaur-16-en-15-one, 7α,20-epoxy-1α,6β,7,14-tetrahydroxy-, (14R)-, NSC 250682, Oridonine, rubescensin A

Beschreibung

A diterpenoid from Chinese medicinal plant Rabdosia rubescens with anti-inflammatory activity. It is a potent inhibitor of NF-κB and MAPK activation and suppresses the release of proinflammatory cytokines. It is also a covalent inhibitor of NLRP3, a sensor component of NLRP3 inflammasome. In a rodent model for cerebral amyloidosis, oridonin effectively prevented neuroinflammation and Alzheimer’s disease-associated neuropathological changes. It reduced numbers of amyloid-β plaques in mice brain and reversed behaviour and social impairment.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 364.44 g/mol
• Formel: C₂₀H₂₈O₆
• Reinheit: Min. 98 Area-%
• Farbe/Form: White Powder