10-Oxo docetaxel

CAS: 167074-97-7

Ref. 3D-FO26648

Produktinformation

• Name: 10-Oxo docetaxel
• Synonyme: (aR,bS)-b-[[(1,1-Dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoic Acid (2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12- (benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano
• Marke: Biosynth
• Beschreibung: 10-Oxo docetaxel is a taxane that is used in the treatment of cancer. It has shown to be effective in the treatment of breast, lung, prostate, and bladder cancers. The impurities of this drug are 10-deacetylbaccatin III (10-DAB) and 10-deacetyltaxol (10-DT). These impurities can be quantified using LC/MS/MS methods with a limit of detection at 0.05% for 10-DAB and 0.1% for 10-DT. The limits of quantification are determined by the peak area response and signal to noise ratio. Bortezomib is an impurity that cannot be removed by chromatographic methods but can be removed by supercritical CO2 extraction. This impurity may cause significant adverse effects on patients receiving this drug as bortezomib inhibits the proteasome which is needed to break down proteins within cells that are damaged or no

Chemische Eigenschaften

• Molekulargewicht: 805.86 g/mol
• Formel: C₄₃H₅₁NO₁₄
• Reinheit: Min. 95%
• Farbe/Form: White Powder