Plitidepsin

CAS: 137219-37-5

Ref. 3D-FP178389

Produktinformation

• Name: Plitidepsin
• Synonyme: Aplidine, 2-9-Didemnin B, 2-(1-(1,2-dioxopropyl)-L-proline)-, Aplidin, Dehydrodidemnin B, Didemnin A, N-(1-(1,2-dioxopropyl)-L-prolyl)-, L-Tyrosine, 1-(1,2-dioxopropyl)-L-prolyl-N-methyl-D-leucyl-L-threonyl-(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl-L-leucyl-L-prolyl-N,O-dimethyl-, (8-3)-lactone, 1-(2-oxopropanoyl)-L-prolyl-N-[(6S,7R,10R,11S,15S,17R,20S,25aS)-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-15-(1-methylethyl)-10-[(1S)-1-methylpropyl]-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-N2-methyl-D-leucinamide

Beschreibung

Plitidepsin is a natural product first isolated from a marine tunicate Aplidium albicans. Plitidepsin has anti-cancer properties as it can induce cell cycle arrest, apoptosis and was also reported to have anti-angiogenic properties. Plitidepsin possesses a potent antiviral activity in vitro against SARS-CoV-2 with IC90 = 0.88nM, which results to be 27.5-fold more potent than the RdRp inhibitor remdesivir. Plitidepsin targets the host protein synthesis factor, eEF1A, and was shown to greatly reduce the subgenomic RNA expression during viral infection.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,110.34 g/mol
• Formel: C₅₇H₈₇N₇O₁₅
• Reinheit: Min. 95%
• Farbe/Form: Powder