LDN 193189

CAS: 1062368-24-4

Ref. 3D-FP43352

Produktinformation

• Name: LDN 193189
• Synonyme: 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 6-(4-(2-(Piperidin-1-Yl)Ethoxy)Phenyl)-3-(Pyridin-4-Yl)Pyrazolo[1,5-A]Pyrimidine, Dm 3189, Ldn 193189, Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

Beschreibung

Inhibitor of ALK1, ALK2, ALK3 and ALK6 kinases and bone morphogenetic protein (BMP) pathway. LDN 1931189 is a dorsomorphin derivative that inhibits BMP-mediated activation of Smad, Akt and p38 signalling. LDN 193189 promotes differentiation of human pluripotent cells into PAX6+ anterior neural ectoderm. In combination with basic fibroblast growth factor (FGF2), LDN 193189 promotes differentiation of mouse pluripotent stem cells into inner ear sensory epithelium.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 406.48 g/mol
• Formel: C₂₅H₂₂N₆
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder
• InChl: InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
• InChI Key: InChIKey=CDOVNWNANFFLFJ-UHFFFAOYSA-N
• SMILES: c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1