Suc-Ala-Phe-Pro-Phe-pNA

CAS: 128802-73-3

Ref. 3D-FS110764

Produktinformation

• Name: Suc-Ala-Phe-Pro-Phe-pNA
• Synonyme: Suc-ala-phe-pro-phe-pna, Suc-apppa, N-(3-carboxypropanoyl)-L-alanyl-L-phenylalanyl-Nalpha-(4-nitrophenyl)-N-[(2S)-pyrrolidin-2-ylcarbonyl]-L-phenylalaninamide, Succinimidyl-alanyl-phenylalanyl-prolyl-phenylalanine 4-nitroanilide

Beschreibung

Suc-Ala-Phe-Pro-Phe-pNA is a recombinant isomerase that has been shown to be an immunosuppressive agent. It is able to catalyze the conversion of cyclosporin A into its two inactive forms, as well as the conversion of cyclophilins A and B into their corresponding inactive forms. The enzyme has also been shown to have chaperone activity. Suc-Ala-Phe-Pro-Phe-pNA has been expressed in Escherichia coli and purified from inclusion bodies using an affinity column with immobilized recombinant cyclophilin A and B. The enzyme's activity was measured by catalysis of the conversion of pNPP, a substrate analogue, into pNPPdG, which can be detected spectrophotometrically at a wavelength of 340 nm. Suc-Ala-Phe-Pro-Phe-pNA shows exponential growth in the presence of

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 700.74 g/mol
• Formel: C₃₆H₄₀N₆O₉
• Reinheit: Min. 95%