Produktinformation
- (R)-9-(2-Phosphonoylmethoxypropyl)adenine1-(6-aminopurin-9-yl)propan-2- yloxymethylphosphonic acid(R)-[[2-(6-Amino-9H-purin-9-
Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.
Chemische Eigenschaften
Technische Anfrage zu: 3D-FT10480 Tenofovir
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