Tritylvalsartan

CAS: 195435-23-5

Ref. 3D-FT146985

Produktinformation

• Name: Tritylvalsartan
• Synonyme: Triphenyl Valsartan, Triphyl valsartan, 3-Methyl-2-[pentanoyl-[[4-[2-(1-triphyltetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid, Trityl valsartan

Beschreibung

Tritylvalsartan is a prodrug that is metabolized to valsartan in the liver. It is an angiotensin receptor blocker (ARB) used for the treatment of chronic liver disease, heart failure and hypertension. Tritylvalsartan is a racemic mixture of two stereoisomers, cilexetil and benzonitrile, which are formed by the Suzuki coupling reaction with a chiral auxiliary. The drug has been shown to be effective in treating cardiovascular diseases with no serious side effects. Tritylvalsartan forms an ion-pair with chloride in the blood plasma and inhibits angiotensin II-induced constriction of blood vessels. It also acts as a competitive antagonist of the angiotensin receptors AT1 and AT2, blocking their activation by angiotensin II.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 677.83 g/mol
• Formel: C₄₃H₄₃N₅O₃
• Reinheit: Min. 95%