Tritylvalsartan
CAS: 195435-23-5
Ref. 3D-FT146985
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Produktinformation
Name:
Tritylvalsartan
Synonyme:
- Triphenyl Valsartan
- Triphyl valsartan
- 3-Methyl-2-[pentanoyl-[[4-[2-(1-triphyltetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid
- Trityl valsartan
Beschreibung:
Tritylvalsartan is a prodrug that is metabolized to valsartan in the liver. It is an angiotensin receptor blocker (ARB) used for the treatment of chronic liver disease, heart failure and hypertension. Tritylvalsartan is a racemic mixture of two stereoisomers, cilexetil and benzonitrile, which are formed by the Suzuki coupling reaction with a chiral auxiliary. The drug has been shown to be effective in treating cardiovascular diseases with no serious side effects. Tritylvalsartan forms an ion-pair with chloride in the blood plasma and inhibits angiotensin II-induced constriction of blood vessels. It also acts as a competitive antagonist of the angiotensin receptors AT1 and AT2, blocking their activation by angiotensin II.
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Marke:
Biosynth
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Chemische Eigenschaften
Molekulargewicht:
677.83 g/mol
Formel:
C43H43N5O3
Reinheit:
Min. 95%
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