Tolbutamide

CAS: 64-77-7

Ref. 3D-FT28304

Produktinformation

• Name: Tolbutamide
• Synonyme: N-[(Butylamino)carbonyl]-4-methyl-benzenesulfonamide1-Butyl-3-(p-tolylsulfonyl)ureaTolylsulfonylbutylurea, 1-Butyl-3-(4-methylphenyl)sulfonylurea, 1-Butyl-3-(p-methylphenylsulfonyl)urea, 1-Butyl-3-(p-tolylsulfonyl)urea, 1-Butyl-3-tosylurea, 3-(p-Tolyl-4-sulfonyl)-1-butylurea, 3-Butyl-1-(4-methylbenzenesulfonyl)urea, Aglicid, Arkozal, Artosin, Artozin, Benzenesulfonamide, N-[(Butylamino)Carbonyl]-4- Methyl-, Butamid, Butamide, D 860, Diaben, Diabetamid, Diabetol, Diabuton, Diasulfon, Dolipol, Glyconon, Hls 831, Ipoglicone, Mobenol, N-(4-Methylbenzene) sulfonyl-N'-butylurea, N-(4-Methylbenzenesulfonyl)-N'-butylurea, N-(4-Methylphenylsulfonyl)-N'-butylurea, N-(Sulfonyl-p-methylbenzene)-N'-n-butylurea, N-(p-Methylbenzenesulfonyl)-N'-butylurea, N-(p-Tolylsulfonyl)-N'-butylcarbamide, N-Butyl-N'-(4-methylphenylsulfonyl)urea, N-Butyl-N'-(P-Tolylsulfonyl)-Harnstoff, N-Butyl-N'-(p-tolylsulfonyl)urea, N-Butyl-N'-p-toluenesulfonylurea, N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide, N-n-Butyl-N'-tosylurea, Nsc 23813, Nsc 87833, Orabet, Oralin, Orezan, Orinase, Orinaz, Oterben, Pramidex, Rastinon, Tolbusal, Tolbutamid, Tolbutamida, Toluina, Tolumid, Tolumide, Toluvan, U 2043, Urea, 1-butyl-3-(p-tolylsulfonyl)-, Willbutamide

Beschreibung

Tolbutamide is a drug that is used to treat diabetes mellitus type 2. It is an inhibitor of the enzyme glucokinase and thus blocks the phosphorylation of glucose, which prevents its utilization by cells. This results in a decrease of blood glucose levels, which can be useful in the treatment of diabetes mellitus type 2. Tolbutamide has shown potent apoptosis-inducing effects on human breast cancer cells and endothelial cells. These effects are thought to be due to inhibition of protein kinase C (PKC) activity by tolbutamide. Additionally, this drug inhibits insulin secretion from pancreatic beta cells and induces cytochrome P450 enzymes, which may lead to increased metabolism of other drugs.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 270.35 g/mol
• Formel: C₁₂H₁₈N₂O₃S
• Reinheit: Min. 95%
• InChl: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
• InChI Key: InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N
• SMILES: CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1