4-thien-3-ylbenzoic acid

CAS: 29886-64-4

Ref. 3D-FT59073

Produktinformation

• Name: 4-thien-3-ylbenzoic acid
• Synonyme: 4-(Thien-3-yl)benzoic acid, 4-(Thiophen-3-Yl)Benzoic Acid, Benzoic acid, 4-(3-thienyl)-, Benzoic acid, p-3-thienyl-, 4-(3-Thienyl)benzoic acid

Beschreibung

4-Thienylbenzoic acid is a reactive compound that binds covalently to the active site of phosphodiesterase type-5 (PDE5) and blocks the hydrolysis of cyclic nucleotides. This leads to an accumulation of cyclic monophosphate, which can lead to alopecia areata. 4-Thienylbenzoic acid has also been shown to induce laser ablation in mice with alopecia areata. The drug has a high affinity for female sex hormone receptors and is transported by drug transporters such as P-glycoprotein. The drug's concentration-time curve is linear and it has a half-life of 2 hours when administered orally at physiological levels. The logistic regression model showed that the body mass index was significantly correlated with 4-thienylbenzoic acid concentrations.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 204.25 g/mol
• Formel: C₁₁H₈SO₂
• Reinheit: Min. 95%