(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil

CAS: 37076-68-9

Ref. 3D-FT76523

Produktinformation

• Name: (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil
• Synonyme: Tegafur, 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (R)-, 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-[(2R)-tetrahydro-2-furanyl]-, 5-Fluoro-1-[(2R)-tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione, NSC 200695, R-1-(Tetrahydrofuran-2-yl)-5-fluorouracil, Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-, (R)-, (R)-Ftorafur

Beschreibung

(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil is a prodrug of 5-FU, which is a chemotherapeutic drug used to treat colorectal adenocarcinoma. It is converted in the body to 5-FU by esterases and glucuronidases, which inhibits DNA synthesis and cell division. (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil has been shown to have anticancer activity in treatment trials with multivariate logistic regression analysis and enzyme activities. The conversion of (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil into 5-FU can be inhibited by using P450 inhibitors such as ketoconazole and erythromycin, suggesting that this pharmacological agent may not be suitable for patients with liver or renal impairment.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 200.17 g/mol
• Formel: C₈H₉FN₂O₃
• Reinheit: Min. 95%
• Farbe/Form: Powder