VE 822

CAS: 1232416-25-9

Ref. 3D-FV137734

Produktinformation

• Name: VE 822
• Synonyme: 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine
• Marke: Biosynth
• Beschreibung: VE 822 is a potent and selective inhibitor of ATR protein kinase, which is derived through chemical synthesis with a high specificity for ATR over related kinases. ATR, or ataxia telangiectasia and Rad3-related kinase, plays a critical role in the cellular response to DNA damage and replication stress. VE 822 achieves its mode of action by interfering with ATR’s catalytic activity, thereby halting the DNA damage response and rendering cancer cells more susceptible to DNA-damaging agents.

Chemische Eigenschaften

• Molekulargewicht: 463.55 g/mol
• Formel: C₂₄H₂₅N₅O₃S
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder
• InChl: InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
• InChI Key: InChIKey=JZCWLJDSIRUGIN-UHFFFAOYSA-N
• SMILES: CNCc1ccc(-c2cc(-c3nc(-c4ccc(S(=O)(=O)C(C)C)cc4)cnc3N)on2)cc1