Trans-4-hydroxy-lomustine

CAS: 56239-24-8

Ref. 3D-GCA23924

Produktinformation

• Name: Trans-4-hydroxy-lomustine
• Synonyme: NSC 239717, Urea, N-(2-chloroethyl)-N′-(trans-4-hydroxycyclohexyl)-N-nitroso-, N-(2-Chloroethyl)-N′-(trans-4-hydroxycyclohexyl)-N-nitrosourea, 1-(2-Chloroethyl)-3-(trans-4-hydroxycyclohexyl)-1-nitrosourea, Urea, N-(2-chloroethyl)-N′-(4-hydroxycyclohexyl)-N-nitroso-, trans-

Beschreibung

Trans-4-hydroxy-lomustine is a pyridinium salt of the anti-cancer drug lomustine, which is used to treat various types of cancers. It is administered orally and has been shown to have antitumour activity in animal studies. Trans-4-hydroxy-lomustine is metabolized by cytochrome P450 enzymes, including CYP2C8, CYP2C9, and CYP3A4. The major metabolites are monohydroxylated trans-4-hydroxy lomustine, which inhibits DNA synthesis and protein synthesis in cells. This drug also has stereoselective effects on tumor cells compared to normal tissue cells. Trans-4-hydroxy lomustine has high lipophilicity due to its quaternary ammonium group.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 249.69 g/mol
• Formel: C₉H₁₆ClN₃O₃
• Reinheit: Min. 95%