4,5-Dichloroisothiazole-3-carboxylic acid

CAS: 131947-13-2

Ref. 3D-GFA94713

Produktinformation

• Name: 4,5-Dichloroisothiazole-3-carboxylic acid
• Synonyme: 4,5-Dichloro-1,2-Thiazole-3-Carboxylic Acid
• CAS: 131947-13-2

Beschreibung

4,5-Dichloroisothiazole-3-carboxylic acid (DCCA) is a cisplatin analog that has been shown to have antiproliferative activity. DCCA binds to the amine group of proteins and forms adducts with a variety of different cells. It has been shown to be cytotoxic to various types of cells in vitro. In vivo, DCCA is metabolized by cytochromes P450 into 4-chloro-5,6-dihydroxyisothiazole, which produces reactive oxygen species that cause apoptotic cell death. DCCA has been shown to have dose-dependent effects on tumor growth in mice when it was administered intraperitoneally and intravenously at concentrations of 25 mg/kg/day and 50 mg/kg/day, respectively.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 198.03 g/mol
• Formel: C₄HCl₂NO₂S
• Reinheit: Min. 95%