SIB-1893

CAS: 7370-21-0

Ref. 3D-HAA37021

Produktinformation

• Name: SIB-1893
• Marke: Biosynth
• Beschreibung: SIB-1893 is a GABA analogue that binds to the gamma-aminobutyric acid receptor and inhibits neuronal death. It has been shown to be neuroprotective in cell culture. SIB-1893 also has potent antagonist effects on glutamate receptors, which may be related to its potential clinical use as an anti-epileptic drug. SIB-1893 does not show any significant binding affinity for other glutamate receptor subtypes, such as AMPA or kainate receptors. The uptake of this drug by cells is dependent on the presence of functional uptake transporters (e.g., GLT1) and the expression levels of these transporters are variable between different cell types. These uptake transporters play an important role in determining the therapeutic efficacy of this drug, since it can only enter cells if they express a functional transporter. Furthermore, SIB-1893 induces necrotic cell death when applied to cultured cells, but apoptotic cell death when injected

Chemische Eigenschaften

• Molekulargewicht: 195.26 g/mol
• Formel: C₁₄H₁₃N
• Reinheit: Min. 95%