CA-074

CAS: 134448-10-5

Ref. 3D-IEC-4322-V

Produktinformation

• Name: CA-074
• Synonyme: Ca 074, N-(3-Propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline, L-Proline, 1-(N-((3-((propylamino)carbonyl)oxiranyl)carbonyl)-L-isoleucyl)-, (2S-trans)-, N-{[(3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline, N-{[3-(propylcarbamoyl)oxiran-2-yl]carbonyl}isoleucylproline

Beschreibung

CA-074 is a research tool that can be used to study protein interactions. CA-074 is a small, synthetic peptide and a potent inhibitor of the ion channel TRPC1. It has been shown to inhibit the calcium currents in HEK293 cells expressing TRPC1 channels. CA-074 inhibits the kinase activity of PLCγ2, which leads to reduced phosphoinositide levels and a decrease in cell proliferation. CA-074 also inhibits PKCδ and PKCε, which are members of the protein kinase C family.
The inhibition of these enzymes by CA-074 causes an increase in the intracellular concentration of diacylglycerol (DAG) and inositol triphosphate (IP3). These two molecules are involved in G protein signaling pathways that regulate cell proliferation, differentiation, and survival.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 383.44 g/mol
• Formel: C₁₈H₂₉N₃O₆
• Reinheit: Min. 95%