W146

CAS: 909725-61-7

Ref. 3D-JLB72561

Produktinformation

• Name: W146
• Synonyme: Phosphonic acid, P-[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, Phosphonic acid, [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-, W 146, P-[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]phosphonic acid, ML 056

Beschreibung

W146 is a small molecule inhibitor of matrix metalloproteinase-9 (MMP-9) that has been shown to be neuroprotective in an animal model of cerebral ischemia. It attenuated neuronal death and reduced the expression of pro-inflammatory cytokines and chemokines after transient focal cerebral ischemia. W146 binds to the active site of MMP-9, preventing it from cleaving a critical protein substrate, which prevents the activation of downstream signaling pathways. This drug also inhibits transcriptional activity and polymerase chain reaction (PCR). W146 has been shown to have anti-inflammatory properties in granulosa cells by inhibiting the production of cytokines and chemokines, such as IL-1β, IL-6, IL-8, TNFα, and MCP-1.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 342.37 g/mol
• Formel: C₁₆H₂₇N₂O₄P
• Reinheit: Min. 95%