PF-06815345

CAS: 2334434-49-8

Ref. 3D-JTD43449

Produktinformation

• Name: PF-06815345
• Marke: Biosynth
• Beschreibung: PF-06815345 is a kinetic convertase inhibitor that binds to the active site of the enzyme, inhibiting its activity. This compound has been shown to inhibit human low-density lipoprotein (LDL) cholesterol production in vitro and reduce plasma LDL-cholesterol levels in vivo. The mechanism of action of PF-06815345 is not clear, but it may be due to inhibition of statin catalysis, which leads to a decrease in the level of functional LDL receptors on liver cells. The drug also inhibits the activity of serine proteases such as subtilisin and kexin type enzymes. In addition, PF-06815345 has been shown to be an organocatalyst for low-temperature aldehyde synthesis, with tetrazole as a key intermediate. It is also used for treatment of cardiovascular diseases such as high blood pressure and elevated levels of low density lipoprotein cholesterol (LDL-C).

Chemische Eigenschaften

• Molekulargewicht: 634.49 g/mol
• Formel: C₂₇H₂₉ClFN₉O₄·HCl
• Reinheit: Min. 95%