Produktinformation
4-(4-Chlorophenyl)-1H-imidazole is a fluorescent probe that has been used to study the substrate binding site of the enzyme cytochrome P450. This probe has been shown to bind to the cavity of the enzyme, which is located at the interface between two domains of the α-subunit. The binding of 4-(4-chlorophenyl)-1H-imidazole has been shown to inhibit catalysis by interfering with substrate binding. Crystallographic analysis and X-ray crystallographic structures have shown that this compound is a tight inhibitor of cytochrome P450. The inhibitor binds in a way that blocks access to the active site, resulting in an increase in Km and decrease in kcat for substrates bound at this site. Functional studies have also shown that 4-(4-chlorophenyl)-1H-imidazole inhibits cytochrome P450 activity, reducing levels of NADPH oxidase and other reactive
Chemische Eigenschaften
Technische Anfrage zu: 3D-KBA51229 4-(4-Chlorophenyl)-1H-imidazole
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