KY-556

CAS: 110816-78-9

Ref. 3D-KEA81678

Produktinformation

• Name: KY-556
• Synonyme: 1,3-Bis-(2-ethoxycarbonylchromon-5-yloxy)-2-(lysyloxy)propane, Ky 556, L-Lysine, 2-((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)-1-(((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)methyl)ethyl ester, dihydrochloride, diethyl 5,5'-{[2-(L-lysyloxy)propane-1,3-diyl]bis(oxy)}bis(4-oxo-4H-chromene-2-carboxylate) dihydrochloride

Beschreibung

KY-556 is a peptide inhibitor of the Kv1.2 voltage-gated potassium channel. It is a potent and selective blocker of Kv1.2 channels, with an IC50 of 0.4 μM and no activity against other voltage-gated potassium channels (Kv1.1, 1.3, 1.6). KY-556 has been shown to inhibit the proliferation of tumor cells by blocking Kv1.2 channels in cell culture experiments and in vivo in mice with implanted melanoma tumors. KY-556 also inhibits the release of inflammatory cytokines such as IL-6 and TNFα from human monocytes and macrophages, suggesting that it may have anti-inflammatory properties as well as tumor suppression capabilities.
KY-556 is synthesized using solid phase peptide synthesis on a Rink amide resin with an N-terminal lysine side chain protecting group and a COOH terminus acid side chain protecting group.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 725.6 g/mol
• Formel: C₃₃H₃₈Cl₂N₂O₁₂
• Reinheit: Min. 95%