Produktinformation
ML095 hydrochloride is a phosphatase inhibitor that has shown anti-tumour activity in vitro and in vivo. It inhibits the enzyme placental alkaline phosphatase (PLAP) by binding to it, thereby preventing the removal of phosphate groups from substrates. This leads to an accumulation of substrate molecules, which may have an effect on cell signalling pathways and biological functions such as cell proliferation and migration. ML095 hydrochloride has been shown to modulate cancer cell growth in vitro and in vivo. This molecule also inhibits the activity of other phosphatases including pancreatic, testicular, and intestinal enzymes.
The compound is a potent inhibitor of bladder cancer cell growth in vitro and in vivo, as well as bladder carcinoma cells that express high levels of PLAP. The compound has been shown to be safe for use by children with cancer or those who have undergone surgery for bladder cancer at doses up to 10 mg/kg body weight.
Chemische Eigenschaften
Technische Anfrage zu: 3D-KVB31857 ML095 hydrochloride
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